2-NBDG uptake, 2-DG uptake, glucose uptake, glycolysis rate and supernatant lactate level were detected to examine the action of fluoxetine on astrocytic glucose metabolism in corticosterone-induced depression, Furthermore, we tried to explore whether GR-TXNIP-GLUT1 pathway play an important role in astrocytic glucose metabolism disturbance in corticosterone-induced depression, and more importantly, to investigate the influence of fluoxetine on this pathway. Here, SLC2A1 is linked to major depressive disorder.