Our previous studies found that the markers (LYVE-1 and PROX1) of epicardial lymphatic vessels in the model of dilated cardiomyopathy induced by Adriamycin were significantly lower than those in normal rats according to the immunohistochemistry results, and it could be effectively reversed by KXF, which also indicates the presence of impaired lymphatic vessels in dilated cardiomyopathy. Here, PROX1 is linked to dilated cardiomyopathy.