Although the underlying molecular mechanisms of Fabp4 expression and activity have not been fully elucidated, Omega-3 fatty acids were reported to decrease the expression and consecutive secretion of Fabp4, which had a positive effect on anti-obesity and reversal of insulin resistance (Furuhashi et al., 2016; Chung et al., 2021). The gene discussed is FABP4; the disease is obesity due to melanocortin 4 receptor deficiency.