AKT1 and hepatocellular carcinoma: Many studies have focused on the signaling pathway in tumor (Gao et al., 2017; Ram Makena et al., 2019), PI3K-Akt signaling pathway and Focal adhesion pathway (Kanteti et al., 2016; Ebrahimi et al., 2017), indicating that those pathways are closely related to the tumorigenesis and metastasis of HCC.