In the TCGA-LUAD dataset, the NEsubtype-panel reclassified 10 (2.04%) ADC samples as LCNEC, which had significantly increased expression of three NE marker genes and significantly decreased expression of the ADC marker gene, respectively, when compared with the signature-confirmed ADC samples (RP algorithm, CD56: p = 0.0253; SYP: p = 0.0253; CHGA: p = 0.0045; NAPSA: p < 0.0001, Figure 5B). The gene discussed is CHGA; the disease is AIDS dementia complex.