For instance, in gene pair RAB3B-KRT16 in the NE-signature of the panel, RAB3B is a Ras oncogene superfamily member that controls the regulated exocytosis in neuronal/secretory cells, and its expression is significantly higher in NE (SCLC) samples than in non-NE (ADC, SCC, and LCC) samples (Zhang et al., 2016); however, keratin 16 (KRT16) is a type I cytokeratin, whose overexpression promotes tumorigenicity in ADC (Yuanhua et al., 2019). Here, RAB3B is linked to leukoencephalopathy with calcifications and cysts.