F3 and neoplasm: Many laboratory data and clinical studies have shown that coagulation-related factors, such as tissue factor (TF), thrombin, plasminogen (PLG), FpA, DDs, TAFI, and thrombin–antithrombin complex, are involved in angiogenesis, tumor cell invasion, tumor progression, and metastasis (Dupuy et al., 2003; Buller et al., 2007).