GH1 and Cushing syndrome due to macronodular adrenal hyperplasia: Supplementary Table S1 details the results. The KEGG analysis (Figures 3E,F) revealed that the pathways enriched by DEGs mainly included transcriptional misregulation in cancer, growth hormone synthesis, secretion and action, endocrine resistance, axon guidance, and Cushing syndrome. Pathview-enriched pathways mainly involved the HIPPO signaling and prion disease pathways (Figures 4A,B).