CENPA and central nervous system cancer: In our study, bioinformatic analyses of TCGA RNA-sequencing data combining GBM and low-grade glioma confirmed increased CENP-A expression which was associated with malignant clinicopathological status (high WHO grade, primary therapy outcome of PD&SD, age > 60, WT IDH status, and absence of 1p/19q co-deletion), short survival time, and poor prognosis.