As shown in the picture, a large majority of cuproptosis-associated genes, including FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, and PDHB were negatively associated with immune, stromal, and estimated scores, which implies that the levels of immune and stromal cells are low across cancers and that tumor purity is high. Here, PDHA1 is linked to cancer.