We found that increased infiltrated immune cells and enhanced functional immune-associated signatures in the low-risk group as compared to the high-risk group (Figure 5A), such as CD8+ T cells, APC-related co-stimulatory and co-inhibitory signals, tumor-infiltrating lymphocytes (TILs), checkpoint inhibitors, and cytolytic activity, suggesting patients in the low-risk group have hot immune reactive activities in anti-tumor immunity. The gene discussed is CD8A; the disease is neoplasm.