Elevated expression of four lncRNAs (LINC00402, RFPL1S, LINC00861, and TTTY14) and reduced LINC02587 in the GS-like group were predicted to be protective factors, while decreased GPR1-AS and AGA-DT expression were risk factors for HNSCC patients. This evidence concerns the gene CMKLR2 and head and neck squamous cell carcinoma.