Many driver genes in HNSCC, such as anti-apoptotic kinase protein kinase C (PIK3CA), transcription factors TP63 and SOX2, and telomerase TERT, MYC, FHIT, and CSMD1, are located in these areas (Ma et al., 2009). The gene discussed is FHIT; the disease is head and neck squamous cell carcinoma.