GCK and diabetes mellitus: In addition, the Varsome (Varsome, 2020) record for this SNP states that the effect of the variant was “Very Strong,” which means “Null variant (intronic within ±2 of splice site) affecting gene GCK, which is a known mechanism of disease (gene has 378 known pathogenic variants, which is greater than minimum of 3), associated with diabetes mellitus, permanent neonatal 1, maturity onset diabetes of the young, type 2, and hyperinsulinemic hypoglycemia, familial 3.”