Additionally, in the genomic region of 9 pleiotropic loci, the causal variants of PCOS are inconsistent with the causal variants that regulate the gene expression (PP3≥ 80.00%) in the whole blood, ovary, and adipose tissues (FDFT1, BLK, FAM167A, NEIL2, CTSB, FAM86B, RP11-297N6.4, ARL14EP, and FTO). This evidence concerns the gene CTSB and polycystic ovary syndrome.