FTO and polycystic ovary syndrome: rs7190396 is an eQTL for FTO in the skeletal muscle and was reported to be strongly associated with menarche in the United Kingdom Biobank GWAS (P = 3 ×10−35), which might partly explain the late menarche phenotype in PCOS patients in a prospective cohort study (Bycroft et al., 2018; Tabassum et al., 2021).