AKT1 and Insulin resistance: The KEGG analysis results showed that targets of YXQNW enriched in some AD-related pathway such as the “PI3K-Akt signaling pathway” (p = 3.48E-16), “insulin resistance” (p = 7.12E-16), and “TNF signaling pathway” (p = 4.20E-15) (Figure 3B), which have been reported to be associated with AD by different groups (Decourt et al., 2017; Kellar and Craft 2020; Wang et al., 2020).