TSC2 and cystic kidney disease: In the multivariate regression, a significantly higher risk of facial angiofibroma was observed for the 11–17 years age group (OR, 2.53), the 18–45 years age group (5.98), TSC2 mutation (1.31), focal seizures (1.50), ADHD (1.47), angiomyolipoma (2.79), and renal cysts (2.63) (Table 1).