One of the main advantages of this methodology is its capacity to recover organisms that elicit IgA responses, which allow for further experimental validation such as testing the immunological impact of identified bacteria in germ-free mice or in vitro cell models.7,9,79,81,82 These experiments have shown that specific, highly immune-reactive members of the human microbiota confer susceptibility to IBD upon transplantation into IBD-models of germ-free mice. The gene discussed is CD79A; the disease is inflammatory bowel disease.