Therapeutics targeting receptors involved in bile acid metabolism can affect microbiome composition.108,109 In parallel, the expression of ileal bile acid transporters, particularly the main transporter, apical sodium-dependent bile acid transporter (ASBT), have been shown to be decreased in animal models of intestinal inflammation, as well as in IBD patients.23,110–112 Therefore, the restoration of bile acid metabolism is gaining attention for its therapeutic potential. This evidence concerns the gene SLC10A2 and inflammation.