Chen et al. (Chen et al. 2022) observed the elevated O-GlcNAc levels in human samples of Sonic hedgehog (Shh)-subtype medulloblastoma and revealed that OGT in granule neuron precursors (GNPs) may contribute to medulloblastoma oncogenesis by activating the Shh signaling pathway via O-GlcNAcylation at S355 of GLI family zinc finger 2 (Gli2). Here, GLIS2 is linked to medulloblastoma.