OGT and familial pancreatic carcinoma: Qian et al. (Qian et al. 2018) revealed that this dysregulation was caused by the disruption of transcriptional regulation homeostasis in pancreatic cancer and proved that it was the abnormal activation of ERK signal transduction in cells that affected OGA-mediated OGT transcription, ultimately resulting in increased OGT expression (Wang et al. 1999; Liptay et al. 2003).