Yao et al. (Yao et al. 2016) revealed that O-GlcNAcylation of tribbles pseudokinase 2 (TRIB2) enhances protein stability, which in turn promotes HBP and O-GlcNAcylation, thus maintaining the transformed phenotype of hepatoma cells. This evidence concerns the gene TRIB2 and hepatocellular carcinoma.