CD274 and familial pancreatic carcinoma: Shang et al. (Shang et al. 2021) observed an enhanced folate cycle, higher concentration of UDP-GlcNAc, and higher cMYC O-GlcNAcylation in patients with pancreatic cancer, which was proven to increase PDL1 (encoding programmed cell death 1 ligand 1) transcription, leading to immune escape.