Notably, they found that hyper-O-GlcNAcylation appeared to be closely related to an indolent clinical course: Elevated O-GlcNAcylation can inhibit JNK signaling, weaken the response of CLL cells to proliferation signals, and hinder the division of CLL cells. The gene discussed is MAPK8; the disease is B-cell chronic lymphocytic leukemia.