Recently, Zhu et al. (Zhu et al. 2019) showed that O-GlcNAcylation of transcription factor YIN-YANG-1 (YY1) at Thr236 could enhance the expression of solute carrier family 22 member 15 (SLC22A15) and aralkylamine N-acetyltransferase (AANAT) and increased its own protein stability, thereby exerting an oncogenic effect in CRC cells. The gene discussed is AANAT; the disease is colorectal carcinoma.