Wu et al. (2019) found that RNA helicase p68/DEAD-box helicase 5 (DDX5) could be O-GlcNAcylated to enhance its stability, thus increasing the activation of the protein kinase B (AKT)/mechanistic target of rapamycin kinase (mTOR) signaling pathway, leading to the promotion of the malignant development of CRC. This evidence concerns the gene AKT1 and colorectal carcinoma.