Wang et al. (Wang et al. 2019) first observed significantly higher OGT and O-GlcNAcylation levels in renal cell carcinoma (RCC) cell lines and tissues compared with those in normal samples, and found that hyper-O-GlcNAcylation was associated with higher grade and poor prognosis in patients. The gene discussed is OGT; the disease is renal cell carcinoma.