Niu et al. (Niu et al. 2017) reported increased levels of O-GlcNAc and OGT in ovarian carcinoma cell lines and showed that O-GlcNAcylation of GTP-bound RhoA and modulator of VRAC current 1 (MLC1) phosphorylation might activate the RhoA/Rho associated coiled-coil containing protein kinase (ROCK)/MLC1 pathway to enhance ovarian cancer cell mobility, thus contributing to ovarian cancer cell migration and invasion. The gene discussed is MLC1; the disease is ovarian cancer.