RACK1 and gastric cancer: Cheng et al. (Cheng et al. 2016a) reported that O-GlcNAcylation of intercellular scaffold protein guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 (GNB2L1) could promote its degradation, thereby blocking the inhibitory effect of GNB2L1 on gastric cancer cell migration, and eventually leading to metastases.