Jin et al. (Jin et al. 2013) reported higher levels of O-GlcNAcylation and OGT mRNA in highly metastatic ovarian cancer HO-8910PM cells compared with low metastatic OVCAR3 cells and revealed the underlying molecular mechanism: hyper-O-GlcNAcylation decreased E-cadherin expression, thereby inhibiting E-cadherin/catenin complex formation, which reduced cell–cell adhesion, leading to cancer cell metastasis. The gene discussed is CDH1; the disease is cancer.