Asthana et al. (Asthana et al. 2018) observed higher OGT and GFAT levels in primary AML cells and revealed that inhibiting the activity of HBP using the GFAT inhibitor 6-diazo-5-oxo-l-norleucine (DON), or using the OGT inhibitors OSMI-1 (OGT with a small molecule inhibitor) and BADGP (benzyl-2-acetamido-2-deoxy-α-d-galactopyranoside), can induce AML cell differentiation and apoptosis, but do not affect normal cells. This evidence concerns the gene OGT and acute myeloid leukemia.