Qiao et al. (Qiao et al. 2012) reported higher O-GlcNAc and OGT levels in patients with esophageal squamous cell carcinoma (ESCC) compared with that in normal samples, they also revealed (Qiao et al. 2016b) that hyper-O-GlcNAcylation could promote tumorigenesis and metastasis of ESCC by raising the stability and expression of MMP9, and changing cellular signal transduction. The gene discussed is MMP9; the disease is esophageal squamous cell carcinoma.