K27M histones’ genes mutations have also been exceptionally reported in other tumor types, such as one desmoplastic/nodular medulloblastoma, SHH-activated [7], one embryonal tumor with multilayered rosettes of the posterior fossa (harboring also a DICER1 mutation) [20], and BRAF-mutant midline gangliogliomas [9, 10, 14]. The gene discussed is BRAF; the disease is neoplasm.