SLC5A2 and type 2 diabetes mellitus: Recent studies have demonstrated that SGLT2 inhibitors exert both direct or indirect protective effects on the cardiovascular and renal systems in T2DM, which are independent of their glucose control effects but related to their effects on blood pressure control, glomerular hemodynamic amelioration, RAAS regulation, and anti-inflammation and in reducing glucotoxicity, lipotoxicity, and uric acid.