Interestingly, Lu et al. found that in diffuse large B-cell lymphoma, STAT3 could inhibit the expression of STAT1 and STAT2, and Li et al. demonstrated that RIG-I could also be repressed by STAT3 in melanoma.(141, 152) Both studies provide evidence for the antagonism between JAK-STAT3 and the IFN-I pathway, which could be a theoretical basis for the combination of STAT3 inhibitors and IFN-α2b. The gene discussed is STAT3; the disease is melanoma.