SQSTM1 and breast carcinoma: Therefore, Xiao et al. constructed another active substance, 4-bromo-N-(2-(dimethylamino)ethyl)-5,12-dihydroindolo[3,2-a]carbazole-6-carboxamide (25), based on the structure of racemosin B. It was demonstrated that compound 25 significantly suppressed breast cancer cell growth and proliferation, as well as induced cell death via the inhibition of autophagy in breast cancer cells through the accumulation of autophagy-related proteins, like LC3-II and p62 [215].