In a study, when harmine derivative, compound 3c, and PI3K inhibitor, LY294002, were combined, they could synergistically inhibit the phosphorylation of Akt and promote the cleavage of PARP and caspase-3, enhancing the apoptosis-inducing effect of compound 3c in CRC cells [133]. Here, AKT1 is linked to colorectal carcinoma.