MAPK-activated protein kinase 2 (MK2), a member of the p38 signaling pathway, can also directly phosphorylate the S90 site of Beclin-1, which is essential for tumor suppression of Beclin-1 protein and can upregulate autophagy levels, maintain cellular homeostasis, and prevent tumorigenesis [192]. The gene discussed is BECN1; the disease is neoplasm.