BAX and lung cancer: The previous experiment has shown that I3C-treated can induce increased expression of ROS in lung cancer H1299 cells, thereby activating the apoptosis-related signaling cascades, accompanied by the increased expression of pro-apoptotic proteins forkhead box O 3 (FOXO3), Bax, and Bim and the decreased expression of anti-apoptotic proteins Bcl-2 and Bcl-xL [84].