PTGS2 and gastric cancer: Harmine has shown to offer anti-gastric cancer effects, both in vitro and in vivo, which suppresses the proliferation, migration, and invasion and stimulates apoptosis of BGC-823 and SGC-7901 cells through the decreased level of cyclooxygenase-2 (COX-2), Bcl-2, and matrix metalloproteinase (MMP)-2 as well as increased Bax level [65].