By inhibiting the interaction between BRCA1-BARD1, BBIT20 triggered BRCA1 cellular relocation, cell cycle arrest, and downregulated the expression of the HDR-related proteins, possibly by proteolytic degradation after the destruction of the BRCA1-BARD1 complex, thus enhancing DNA damage, ROS generation and apoptosis in triple-negative breast cancer and ovarian cancer cells [158]. Here, BRCA1 is linked to triple-negative breast carcinoma.