BCL2 and gastric cancer: Wang et al. investigated the cytotoxicity of bufothionine against gastric cancer (GC) cell lines and reported that bufothionine could inhibit the growth and evoked apoptotic cell death of GC cells by promoting the cleavage of caspase-3/8/9, downregulating the Bcl-2 level, and upregulating the Bax level [101].