Recent studies have shown that mutations and deregulation in SAC-related genes, including budding uninhibited by benzimidazole-1 (BUB1) and BUB3 [14], BUB1-related kinase (BUBR1), BUB1B, mitotic arrest-deficient-3 (MAD3) [15], the monopolar spindle 1 (Mps1/TTK) [16], MAD1 [17] and cell division cycle-20 (CDC20) [18] are related to the occurrence and development of CRC. Here, TTK is linked to colorectal carcinoma.