This is the first study to verify that the expression of NudCD1 protein in colorectal cancer is significantly higher than that in normal intestinal mucosa, and that its degree of expression is related to the degree of differentiation of the tumour, the TNM stage, the depth of invasion of the primary tumour and lymph node metastasis. This evidence concerns the gene NUDCD1 and metastatic malignant neoplasm in the lymph nodes.