CHCHD6 and Alzheimer disease: PLA-positive puncta between anti-APP and anti-CHCHD6 antibodies were also observed in WT, APPNL−G−F KI, and 5XFAD mouse hippocampus, with significantly reduced interaction in AD mice (Fig. 3d, Supplementary Fig. 3g and h) likely due to the reduced levels of CHCHD6.