We next visualized hippocampal CHCHD6 expression in AD mice and human AD brain tissue by immunofluorescence, and observed age-dependent decreases in APPNL−G−F and 5XFAD mice, compared to age-matched WT mice (Fig. 2a and b, Supplementary Fig. 2a and b). Here, CHCHD6 is linked to Alzheimer disease.