GZMB and neoplasm: Levels of granzyme B using IHC detection in 4T1-IseS vs 4T1 tumor pair (Fig. 4c and Supplementary Fig. S4c) and BT474-IdeS vs BT474 tumor pair (Fig. 4d and Supplementary Fig. S4d) showed significant reductions in scIgG containing (+IdeS) tumors than that in their counterpart control tumors.