The present study presents a prespecified sub-analysis of the MUSCAT-HF study to compare the effects of an SGLT2 inhibitor and an alpha-glucosidase inhibitor on atherogenic lipoproteins (MDA-LDL and small-dense LDL cholesterol) and inflammatory markers (adiponectin and high-sensitivity CRP), as related to the incidence of ASCVD in diabetes patients with heart failure. This evidence concerns the gene SLC5A2 and heart failure.