In the subanalysis using the RCT data of patients with type 2 diabetes and heart failure, the SGLT2 inhibitor (luseogliflozin) did not significantly reduce the serum levels of MDA-LDL or small-dense LDL cholesterol after treatment when compared with the ɑ-glucosidase inhibitor, voglibose. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.