NNMT and obesity due to melanocortin 4 receptor deficiency: Likewise, as previously shown for a structurally distinct series of NNMT inhibitors, JBSNF-000028 had little influence on body weight, glucose and lipids in ob/ob or db/db mice, two models of severe obesity driven by lack of leptin signaling that NNMT inhibition may not be strong enough to override6.