In particular, FLT3 was consistently overexpressed in ALL cases harboring ZNF384 fusions with a variety of partner genes, e.g., EP300, TCF3, TAF15, ARID1B, CLTC, CREBBP, EWSR1, NIPBL, and SMARCA2 (Fig. 1b). The gene discussed is CLTC; the disease is acute lymphoblastic leukemia.