TP53 and chronic myelogenous leukemia, BCR-ABL1 positive: However, FBXW7 was reported to confer radiation survival by targeting the tumor suppressor p53 for degradation [10–12] and regulate chronic myelogenous leukemia (CML) via a p53-dependent apoptosis pathway [13], which adds another layer of complexity to the role of FBXW7 in tumorigenesis.