Compared to B-MF, FOB upregulated numbers of CD4+ T cells but decreased frequency of IL10+ CD4+ T cells and GrB+ and Lamp1+ (cytolytic) CD8+ T cells in the tumor (Supplementary Fig. 6h), implying that the two cells support cancer independently and without reversal of B-MF to B cells. This evidence concerns the gene GZMB and cancer.