Adding to evidence, B16-F10 cells proliferated more when cultured in medium supplemented with tumor explant supernatant (TES) from HFHCD compared to TES from CD-derived tumors (Supplementary Fig. 3h), and higher Ki67 proliferation index in situ was observed in tumors under HFHCD (Fig. 2k). Here, MKI67 is linked to neoplasm.