LMNA and autoimmune polyendocrinopathy: Depending on the samples, we observed between 70,497 and 137,900 DMPs in pathological samples compared with controls with a global trend toward hypermethylation (Fig 3A and Table S2) that is more pronounced when comparison is made with the young donor (Fig 3B and C; CT-Y; HyperM APS, 65.5%; HGPS, 83.2%; HGPS-L, 79%) than with the aged donor (CT-A; 39% for APS, 59.15% for HGPS, and 61.43% for HGPS-L).