Altogether, our data showed common hallmarks in MSCs derived from patients with premature aging syndromes linked to LMNA mutations (DNA damage response and nuclear and mitochondrial abnormalities), regardless of the type of mutation, but possibly linked to different pathways depending on the presence (HGPS, HGPS-L) or absence (APS) of truncated prelamin A isoforms, including progerin. The gene discussed is LMNA; the disease is premature aging syndrome.