By considering more specifically the accumulation of γH2AX foci at telomeres, we found a marked and significant increase in telomere induced foci (TIFs) in the different diseases compared with controls (P < 0.01 for HGPS; P < 0.0001 for HGPS-L and APS; Holm-Sidak’s multiple comparisons test) that correlates with the loss of telomeric signal in HGPS but not in HGPS-L and APS (Fig 5D). Here, LMNA is linked to autoimmune polyendocrinopathy.