LMNA and Hutchinson-Gilford progeria syndrome: At the cellular level, HGPS pathogenesis has been linked to a variety of causes, associated with the accumulation of progerin, which is toxic to cells, but also the fragility and disruption of the nuclear lamina resulting in nuclear blebbings, chromatin reorganization, premature cell senescence, increased sensibility to mechanical stress, and defects in autophagy (8, 9, 10).