To this aim, we produced induced pluripotent stem cells (hiPSCs) from patients affected with premature aging syndromes linked to different LMNA mutations (HGPS, n = 3; HGPS-L, n = 1; and APS, n = 3), established a differentiation protocol to obtain MSCs, and analyzed their transcriptome and methylome in comparison to cells from a healthy young donor and a healthy aged donor, used as controls. This evidence concerns the gene LMNA and premature aging syndrome.