COL1A1 and COL1A2 are down-regulated in cells producing progerin or truncated prelamin A (HGPS; HGPS-L, P < 0.01; Kruskal–Wallis test) but up-regulated in APS cells (P < 0.01; Kruskal–Wallis test). The gene discussed is COL1A1; the disease is autoimmune polyendocrinopathy.