LMNA and Hutchinson-Gilford progeria syndrome: In cells from patients with premature aging (HGPS, HGPS-L and APS), the mitochondrial network presented distinctive patterns and appeared more fragmented and concentrated at the periphery of the nucleus in APS, HGPS, and more particularly in HGPS-L cells (87% ± 16, P < 0.0001; Tukey’s multiple comparisons test).