LMNA and Hutchinson-Gilford progeria syndrome: Concomitant with the expression of progerin and accumulation of nuclear abnormalities (Fig 5A), we observed a significant increase in γH2AX foci in HGPS, HGPS-L, and APS cells compared with controls (P < 0.0001, Holm-Sidak’s multiple comparisons test; Fig 5C and D).