LMNA and Hutchinson-Gilford progeria syndrome: In 2007, a heterozygous mutation in the LMNA gene (p.T623S) was found in an 11-yr-old girl presenting with a phenotype similar to HGPS (15), including facial dysmorphism, alopecia, low bone mass, cardiovascular defects, increased triglyceride, LDL, and cholesterol levels.