LMNA and autoimmune polyendocrinopathy: Overall, our comparison of MSCs from patients with premature aging, and accumulating or not progerin or truncated prelamin A, suggests that in these cells, LMNA splice mutations (HGPS and HGPS-L) or point mutations (APS) have different consequences on the epigenetic and transcriptomic landscape with HGPS and HGPS-L cells more closely resembling to cells from an aged donor than APS cells.