Skin burn will first destroy the immune system, but the body will self-regulate in a short time to resist environmental microbial infection, improve immunity, and enhance the expression of inflammatory factors and related genes.21 NF-KB-dependent signaling pathways, TNF signaling pathways, and IL-17 signaling pathways have long been found to play an important role in skin burns. The gene discussed is NFKB1; the disease is burn.