Consistent with mTOR’s critical role in the development, homeostasis, and function of myeloid cells and T cells (Lachmandas et al., 2016; Powell et al., 2012; Sinclair et al., 2017; Weichhart et al., 2015), therapeutic mTOR blockade in organ transplantation and cancer has been associated with increased risk of infections, including TB (Fijałkowska-Morawska et al., 2011; Garcia and Wu, 2016; Jeon et al., 2017; Ruiz-Camps and Aguilar-Company, 2021; Tsai et al., 2007). This evidence concerns the gene MTOR and cancer.