Many poxvirus proteins inhibit DNA sensing and IFN-I induction through different mechanisms, such as direct degradation of 2’, 3’-cGAMP by Poxins [9,10], inactivation of STING through mTOR by VACV F17 [12], inhibition of IRF3 by VACV C6 [41], and inhibition of NF-κB activation by many VACV proteins including B14 [42] and F14 [43], etc. More importantly, inhibition of host DNA sensing by poxviruses during early infection seems to be a common strategy in spite of their species tropism. This evidence concerns the gene IRF3 and infection.