IRF3 and infection: We reason that such effect reflected in the transcriptional regulation is unlikely due to additional extracellular stimuli such as from paracrine/autocrine IFN-I responses, since ΔM062R induced IRF3 phosphorylation starts at 4 hours post-infection and persists at 16 hrs p.i., while 2’3’-cGAMP production can be observed at 8 hrs p.i..