Cells were cultured with stimulators that preferentially induce TD and GC (anti‐IgM/G/A plus IL‐2, IL‐10, and sCD40L) response or stimulators (anti‐IgM/IgG/A plus CpG) that preferentially promote EF response46, 47, 48 We found that all B‐cell samples from HDs showed proliferative responses with relatively consistent proliferation rates. This evidence concerns the gene IL2 and thanatophoric dysplasia.