Prexasertib (LY2606368) was developed by Eli Lilly as a Chk1/2 inhibitor with an IC50 of 8 nM for Chk2 and has been used in phase 2 clinical trials in prostate cancer (NCT02407054) and in 18 other studies that include solid tumors and blood cancers (e.g., NCT03057145, NCT02555644, and NCT03735446). This evidence concerns the gene CHEK1 and Familial prostate cancer.