TMEM200B and hepatocellular carcinoma: The relationship between bTMB and tTMB has not yet been evaluated in HCC, and it remains unclear whether clinico-genomic factors may be associated with TMB.5 In this work, we define the landscape of bTMB in advanced HCC using a commercially available targeted next-generation sequencing (NGS) assay and show that bTMB and tTMB are significantly correlated with bTMB being approximately 3 times as high as tTMB.