CARM1 and Duchenne muscular dystrophy: Corroborating these results, selective ablation of Carm1 in satellite cells leads to a reduction in asymmetric satellite cell divisions resulting in hyperplasia of satellite cells that do not commit to myogenesis and impaired muscle regeneration.23 Perhaps coincidentally, muscles from patients with Duchenne muscular dystrophy and a dystrophic mouse model (mdx mouse) also display satellite cell hyperplasia and impaired regeneration.21,29 Moreover, satellite cells from mdx mice display a significant reduction in asymmetric divisions,21 suggesting CARM1 might be misregulated in mdx.