Then, 13 eligible genes were further filtered using LASSO regression analysis to eliminate multicollinearity and seven eligible genes (FBXL22, MTA1, TP53, RORC, DRD4, PPARGC1A, ZFHX3) were eventually acquired for establishment of a CR-related gene signature for predicting RFS in PRAD patients (Figure 1E, 1F). The gene discussed is FBXL22; the disease is prostate adenocarcinoma.