To identify eligible CR-related genes in PRAD, we first performed univariate Cox regression analysis for 117 CR-related genes, and obtained 13 genes (FBXL22, FBXL6, MTA1, NR2F6, TP53, BTRC, GHRL, RORC, CIPC, DRD4, MTOR, PPARGC1A, ZFHX3; P<0.05; Figure 1D). The gene discussed is FBXL22; the disease is prostate adenocarcinoma.