However, in the presence of CPT, the proportion of cells labelled with annexin V-PE in the HCC cell lines stably expressing HBx-TM was significantly higher than in the HCC cell lines stably expressing HBx-WT (Figures S9B and S9D), indicating that HBx-T81P/S101P/L123S is likely to increase the genomic instability in HCC cells compared with wild-type HBx. Here, ANXA5 is linked to hepatocellular carcinoma.