TNFRSF11B and breast cancer: This triggers gene expression in ECs that promoted metastasis where expression of four factors, INHBB (inhibin β B), laminin α1, osteoprotegerin (OPG) and secreto-globulin family 3A member 1), were found to be crucial and correlated with worsened survival of breast cancer patients (Hongu et al., 2022) (Fig. 2D).