In tongue oral squamous cell carcinoma (OSCC) (Spenlé et al., 2020) and the MMTV-NeuNT and NT193 breast cancer progression models (Murdamoothoo et al., 2021), TNC upregulated and bound the chemokines CCL21 and CXCL12, respectively, thereby attracting and retaining tumor-infiltrating leukocytes (TILs) in the stroma. This evidence concerns the gene CXCL12 and neoplasm.