FMR1 and fragile X syndrome: FMRP was found to be associated with key components of the miRNA biogenesis pathway, including Ago1 and Dicer (Jin et al. 2004), and to bind to several miRNAs, such as bantam, let-7, miR-125b, miR-132, and miR-181d (Yang et al. 2009; Edbauer et al. 2010; Wang et al. 2015), suggesting that miRNA dysfunction may contribute to FXS.