MAPT and Alzheimer disease: 2020). The main pathological changes of AD are senile plaques with amyloid-β protein as the core, neurofibrillary tangles formed by abnormal aggregation of hyperphosphorylated Tau protein, and loss of hippocampal neurons (Mohamed et al. 2016). Both amyloid-β and Tau can induce oxidative stress and contribute to AD pathogenesis (Zhao and Zhao 2013; Cheignon et al. 2018).