2020). Molecular docking is a theoretical simulation method for predicting intermolecular binding patterns and affinity, predicting drug target interactions with high efficiency and low cost (Wu et al. 2018). Based on previous studies, we analyzed the key targets and signal pathways of UA and ATS on AD by using network pharmacology and molecular docking methods, and verified that the combination of UA and ATS can inhibit the apoptosis of PC12 cells induced by H2O2 through cell experiments and the mechanism may be related to the regulation of Akt/mTOR signalling. This evidence concerns the gene AKT1 and Alzheimer disease.