2020). VEGF is a critical factor that promotes angiogenesis and has a protective effect on the nervous system. Studies have shown that VEGF has a protective effect on cognitive function in AD models by improving mitochondrial dysfunction (Liu et al. 2021) and escalating mitochondrial number, and shrinking Aβ production and deposition (Guo et al. 2019). Here, VEGFA is linked to Alzheimer disease.