Consistent with this, aging and AD rodent models exhibit aberrant calcium-dependent CaN/NFAT signaling (Foster et al., 2001; Norris et al., 2005), and blocking CaN/NFAT in AD models improves synaptic function, amyloid pathology and astrogliosis (Furman et al., 2012). This evidence concerns the gene NUP214 and amyloidosis.