Regular physical exercise, associated with reductions in lipid profile and dysfunctional adipose tissue as one of the major outcomes, may result in a reduction in the inflammatory condition of this population, considering that excessive visceral adipose tissue in individuals with obesity is related to the release of adipokines and other inflammatory cytokines, such as IL-1, IL-2, IL-6, and alpha and beta interferons.43 Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.