Type 2 diabetes mellitus (DM2) is a metabolic disorder caused by a combination of decreased insulin secretion and decreased insulin sensitivity in peripheral tissues, primarily in the liver, muscles and adipose tissue as target organs.1 Currently, glycemia levels and glycated hemoglobin-A1c (HbA1c) are the gold-standard parameters for diagnosing and monitoring DM2. The gene discussed is INS; the disease is Other metabolic disease.