Using our in‐house series of resected human PDAC samples and public ICGC data set, we found that POSTN‐high tumors, assessed by IHC or using RNAseq signature, were associated with (1) shorter OS ([10]), (2) poor prognostic (basal‐like/poorly differentiated) PDAC epithelial subtypes [10], (3) higher tumor cellularity and lower abundance of collagen deposits, particularly when tumors display only POSTN expression, without MYH11 or PDPN expression, and (4) with infiltration by M2 macrophages. The gene discussed is POSTN; the disease is neoplasm.