Sulfonylurea was consistently associated with a higher risk of VA/SCD in patients without a history of valvular heart disease or cardiomyopathy (HR, 1.97 [95% CI, 1.79–2.17]), without a history of heart failure (HR, 1.94 [95% CI, 1.76–2.14]), and in both insulin users (HR, 1.82 [95% CI, 1.52–2.18]) and nonusers (HR, 1.92 [95% CI, 1.73–2.13]). The gene discussed is INS; the disease is cardiomyopathy.