Mice harbouring targeted deletions of either IL‐1β, IL‐1R1,6, 7 activating enzymes of IL‐1β, for example, nucleotide‐binding domain, leucine‐rich‐containing family, pyrin domain‐containing‐3 (NLRP3) inflammasome components,8, 9, 10 or neutrophil serine proteases11 are protected from diet‐induced metabolic inflammation and insulin resistance. The gene discussed is IL1R1; the disease is Insulin resistance.