IL1B and Insulin resistance: Mice harbouring targeted deletions of either IL‐1β, IL‐1R1,6, 7 activating enzymes of IL‐1β, for example, nucleotide‐binding domain, leucine‐rich‐containing family, pyrin domain‐containing‐3 (NLRP3) inflammasome components,8, 9, 10 or neutrophil serine proteases11 are protected from diet‐induced metabolic inflammation and insulin resistance.