In a murine model of NAFLD, employing an obesogenic HFD over 12 weeks we observed a 3.6 (± 0.3)‐fold upregulation of IL‐1R1 mRNA in liver tissue (p < .01 for HFD vs. CD using unpaired, two‐tailed Student's t test, n = 7 mice/group, data not shown). This evidence concerns the gene IL1R1 and metabolic dysfunction-associated steatotic liver disease.