Improved mitochondrial integrity seemed to be also reflected by heme oxygenase (HO)‐1, a further downstream target of PGC‐1α, which plays a protective role against the oxidant injury accompanying inflammatory processes in NAFLD28 and suppresses steatosis by modifying fatty acid turnover, among others, via Sirtuin 1.29 This evidence concerns the gene HMOX1 and steatosis.