Improved mitochondrial integrity seemed to be also reflected by heme oxygenase (HO)‐1, a further downstream target of PGC‐1α, which plays a protective role against the oxidant injury accompanying inflammatory processes in NAFLD28 and suppresses steatosis by modifying fatty acid turnover, among others, via Sirtuin 1.29 The gene discussed is SIRT1; the disease is steatosis.