Supporting this finding, IL‐1α/β protein significantly increased CXCL1 and CXCL2 mRNA levels in isolated primary WT hepatocytes in vitro (Figure S7D,E) as well as their functional homolog CXCL8 in human HepG2 cells and primary hepatocytes in an NF‐κB‐dependent manner (Figure S8D,E), pointing to a mild immunomodulatory activity of the hepatocyte IL‐1R1 pathway in early stage NAFLD. This evidence concerns the gene IL1A and metabolic dysfunction-associated steatotic liver disease.