Disruption of IL‐1R1 signalling was associated with moderate SIRT1 induction and an increase in LC3B II protein levels under HFD conditions,64 increasing the liver capacity of Il1r1Hep−/– mice to oxidize lipids and to activate autophagy processes, thus preventing steatosis aggravation and insulin resistance. The gene discussed is SIRT1; the disease is Insulin resistance.