MMP-13, an important member of the MMPs family, performs well-measured functions through degradation of type II collagen in articular cartilage and bone in osteoarthritis, concerns the molecular metastases of oral cancer, and should alter vasculogenic mimicry and endothelial-dependent vessel formation in large cell lung cancer.29–31 Similar studies using the expression of MMP-13 have proven that MMP-13 plays a role in every phase of wound healing by making modifications to the wound matrix, enabling cell migration essential in the remodeling process. The gene discussed is MMP13; the disease is lip and oral cavity carcinoma.