It has been reported that miR-125a-5p could serve as a diagnostic or prognostic biomarker for renal cell carcinoma [41], and exosomal miR-125a-5p has been shown to be higher in the placental tissues of women with preeclampsia and to suppress VEGF-A expression and angiogenesis in the peripheral blood of patients with preeclampsia [42]. Here, VEGFA is linked to hereditary clear cell renal cell carcinoma.